Welcome to When It Goes Wrong, the podcast about disasters, accidents and when things fall apart. On this episode, I discuss drug trials which have gone wrong and resulted in catastrophic side effects for the participants. I discuss the Theraluzimab trial along with the current covid vaccine trials.

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Sources:

Drug development:

https://mstrust.org.uk/a-z/drug-development-process

https://en.wikipedia.org/wiki/Drug_development

https://www.nhs.uk/conditions/clinical-trials/

TGN:

https://www.bbc.com/news/magazine-35766627

https://en.wikipedia.org/wiki/Theralizumab

https://www.reuters.com/article/us-drug-comeback-exclusive/exclusive-drug-that-caused-elephant-man-side-effect-makes-comeback-after-2006-disaster-idUSKBN0MK1SQ20150324

https://www.huffingtonpost.co.uk/entry/the-drug-trial-bbc-examines-what-went-wrong-in-the-infamous-elephant-men-case_uk_58ac3bd1e4b07028b703c926

The drug trial documentary on BBC / youtube

BIA:

https://en.wikipedia.org/wiki/BIA_10-2474

https://edition.cnn.com/2016/05/23/health/fatal-french-drug-trial-investigation/index.html

https://www.theguardian.com/science/2016/mar/07/french-drug-trial-man-dead-expert-report-unprecidented-reaction

https://www.reuters.com/article/us-health-france-test-idUSKCN0WI007

Covid:

https://theconversation.com/explainer-how-clinical-trials-test-covid-19-vaccines-146061

https://theconversation.com/coronavirus-vaccine-understanding-trial-results-roll-out-and-what-happens-next-an-expert-guide-151971

https://www.nhs.uk/conditions/coronavirus-covid-19/coronavirus-vaccination/coronavirus-vaccine/

https://www.swlstg.nhs.uk/news-and-events/latest-news/item/vaccine-safety-and-myths-busting

https://britishima.org/operation-vaccination/hub/covidmyths/

https://www.nature.com/articles/d41586-020-03441-8